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Diplomat welcomes patients with X-linked lymphoproliferative disease (XLP) and offers customized programs that give the entire health care team the resources they need to help patients succeed. We understand the unique needs of patients and know that living with a rare genetic disease can be challenging. We also know that the treatments used to cope with a defective immune system response may seem complex and confusing, even to an experienced patient. That’s why we’re here—to act as a guide throughout therapy. We provide the proper immune globulin or infection management therapy, uncover funding options and answer clinical and personal questions 24/7.

X-Linked Lymphoproliferative Disease

One of the first steps after an X-linked lymphoproliferative (XLP) disease diagnosis is understanding the condition. The information on this site and linked sites is not meant to replace your physician’s advice, medical care or a diagnosis. If you have questions about your disease, please ask your prescriber.

Overview

X-linked lymphoproliferative disease is a genetic condition characterized by a defective immune system. It occurs in about one in a million males worldwide. Although XLP is genetic, it might not be diagnosed until well into childhood. Symptoms typically occur in response to an episode of Epstein-Barr virus (EBV), a common disease in the herpesvirus family that will affect most people in their lifetime.

As a patient responds to EBV, their body will create an overabundance of immune cells. This potentially fatal reaction can trigger hemophagocytic lymphohistiocytosis (HLH), a life-threatening condition. The HLH reaction puts the patient at risk for hepatitis and lymphoma after exposure to EBV.

XLP causes no symptoms until a patient is infected with EBV, though blood tests might show it. Treatment with immunoglobulin G (IgG), with or without antibodies to EBV, can help prevent or treat the infection.

Sources

National Institute of Allergy and Infectious Diseases
National Organization for Rare Disorders

The information contained herein may not be construed as medical advice. It is for educational purposes only. Diplomat Pharmacy Inc. takes no responsibility for the accuracy or validity of the information contained herein, nor the claims or statements of any manufacturer.

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Resources

  • Can I Use Diplomat?

    Can I Use Diplomat?

    We provide benefits investigation and help verify your eligibility for our programs and services. Fill out a simple form and we’ll get in touch with you.
  • Financial Assistance

    Financial Assistance

    We help connect patients with nonprofit, manufacturer-sponsored and third-party funding options to keep therapy affordable.
  • PIDD Post Newsletter

    PIDD Post Newsletter

    Sign up to receive helpful information on infusion management and treatments, stories from the community, and tips to thrive with a primary immune deficiency.
  • Pregnancy Brochure

    Pregnancy Brochure

    Our PIDD Pregnancy Brochure brochure helps expectant mothers with PIDD and families prepare for pregnancy and a new baby.
  • Off to College Brochure

    Off to College Brochure

    This brochure provides a helpful checklist and tips for families and students with PIDD to make the transition from home to school as easy as possible.
  • Back-to-School Brochure

    Back-to-School Brochure

    Developed by a nurse and mother of a PIDD patient, this brochure helps parents and children take simple steps to make the school year a success.
  • Consumer Advocacy Program

    Consumer Advocacy Program

    Many of our consumer advocates are members of the primary immune deficiencies community themselves. They’re here to guide patients through the often complex world of health care.

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