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At Diplomat, we’re proud to offer customized treatment programs that combine therapies and education for patients with X-linked agammaglobulinemia (XLA). We understand the unique needs of patients and the challenges of dealing with infections, autoimmune issues and prescription regimens that can often be complicated. That’s why we act as a guide, providing patients with the proper immune globulin or infection management therapy and giving them the resources they need to stay on track. We uncover funding options, answer questions 24/7 and communicate thoroughly to keep the entire health care team on the same page.

X-Linked Agammaglobulinemia

One of the first steps after an X-linked agammaglobulinemia (XLA) diagnosis is understanding the condition. The information on this site and linked sites is not meant to replace your physician’s advice, medical care or a diagnosis. If you have questions about your disease, please ask your prescriber.

Overview

X-linked agammaglobulinemia, also known as Bruton agammaglobulinemia, is caused by a mutation in a gene found in the X chromosome. This mutation affects the ability of the body to fight infections. Because it is an X-linked mutation, XLA mostly affects boys.

Symptoms often start around six months in age. As protective antibodies from the infant’s mother wear off, patients with XLA are unable to produce enough B cells, compromising the body’s ability to fight infection. In rare cases, symptoms might not occur until the patient is a teenager.

XLA is extremely rare, occurring in only one in 200,000 newborns. Children with XLA might cope well with short-term viral infections but are susceptible to chronic viral infections such as hepatitis and polio. Common bacterial infections in XLA patients include ear infections, pink eye, pneumonia, sinus infections and other infections causing diarrhea.

Regular immune globulin treatment can offer XLA patients the antibodies crucial to their health.

Sources

Immune Deficiency Foundation
Genetics Home Reference

The information contained herein may not be construed as medical advice. It is for educational purposes only. Diplomat Pharmacy Inc. takes no responsibility for the accuracy or validity of the information contained herein, nor the claims or statements of any manufacturer.

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Resources

  • Can I Use Diplomat?

    Can I Use Diplomat?

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  • Financial Assistance

    Financial Assistance

    We help connect patients with nonprofit, manufacturer-sponsored and third-party funding options to keep therapy affordable.
  • PIDD Post Newsletter

    PIDD Post Newsletter

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  • Pregnancy Brochure

    Pregnancy Brochure

    Our PIDD Pregnancy Brochure brochure helps expectant mothers with PIDD and families prepare for pregnancy and a new baby.
  • Off to College Brochure

    Off to College Brochure

    This brochure provides a helpful checklist and tips for families and students with PIDD to make the transition from home to school as easy as possible.
  • Back-to-School Brochure

    Back-to-School Brochure

    Developed by a nurse and mother of a PIDD patient, this brochure helps parents and children take simple steps to make the school year a success.
  • Consumer Advocacy Program

    Consumer Advocacy Program

    Many of our consumer advocates are members of the primary immune deficiencies community themselves. They’re here to guide patients through the often complex world of health care.

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