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Through treatment and patient education, we are proud to support patients with stiff-person syndrome (SPS). Patients with SPS often experience symptoms involving progressive muscle rigidity and prolonged—often severe—muscle spasms. While SPS is primarily a rare disease of the nervous system, autoimmune disorders are also common in these patients. We are here not only to provide immune globulin therapies, muscle relaxers and pain relievers to patients in need, but to act as a teammate, guiding them every step of the way. We help uncover funding assistance, manage side effects and offer a listening ear 24/7.

Stiff-Person Syndrome

One of the first steps after a stiff-person syndrome (SPS) diagnosis is understanding the condition. The information on this site and linked sites is not meant to replace your physician’s advice, medical care or a diagnosis. If you have questions about your disease, please ask your prescriber.


Stiff-person syndrome, which is believed to affect less than one in a million people, involves muscle spasms and fluctuating rigidity in patients’ torsos and limbs. Spasms are often caused by external stimuli such as loud noises (e.g., an emergency vehicle siren), touch or emotional distress. Because of their heightened sensitivity, it can be difficult for patients to leave home.

Muscle spasms vary in severity and duration. In extreme instances, SPS patients suffer broken bones due to muscle spasms or have limited mobility. SPS affects both men and women, but women suffer about twice as often.

With treatment, SPS patients are often able to attain a better quality of life that might allow them to manage daily interactions that might otherwise be impossible.


National Organization for Rare Disorders
National Association of Neurological Disorders and Stroke

The information contained herein may not be construed as medical advice. It is for educational purposes only. Diplomat Pharmacy Inc. takes no responsibility for the accuracy or validity of the information contained herein, nor the claims or statements of any manufacturer.

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