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Factor X deficiency, or Stuart-Prower factor deficiency, is a rare bleeding disorder caused by low blood levels of a protein called coagulation factor X. It affects about one person per million worldwide and can vary in severity. The most severe cases occur in childhood, although symptoms can begin at any age.

The disorder can cause bleeding from the nose, from the gums, and under the skin; blood in the urine; easy bruising; and abnormal bleeding after surgery or trauma. Women might have heavy or prolonged bleeding during menstruation or in childbirth, and they might have increased risk of pregnancy loss. Patients with lower levels of coagulation factor X tend to have more severe symptoms, which can include bleeding inside the skull, lungs, or gastrointestinal tract.

Factor X deficiency can be inherited or acquired.

  • The inherited form is caused by mutations in the F10 gene, which provides instructions for making coagulation factor X. These mutations can lead to Type 1 factor X deficiency, in which the blood doesn’t have enough coagulation factor X, or Type 2 factor X deficiency, in which the coagulation factor X doesn’t work.
  • The acquired form can be caused by other disorders, such as severe liver disease or systemic amyloidosis. It can be caused by certain drugs (such as medicines that prevent clotting) or by a deficiency of vitamin K.

Traditionally, factor X deficiency was treated with prothrombin complex concentrates, which carried the risk of blood clots. Today, factor X deficiency can be treated with Coagadex®, a purified factor X concentrate available through Diplomat Specialty Infusion Group.

Sources: Genetics Home Reference, Food and Drug Administration, National Hemophilia Foundation

Reference to a specific product, process, or service does not constitute an endorsement or recommendation by Diplomat Pharmacy Inc., and any such reference is provided for educational purposes only.

Products We Support


  • ACT10N logo

    With ACT10N, patients with factor X deficiency have access to a highly specialized infusion care program, complete with personal support, clinical care and monitoring.

  • REBUILD logo

    Physical therapy is key to comprehensive hemophilia management. REBUILD facilitates training and connections between hemophilia patients and their local physical therapists.

  • IMPACT logo

    A comprehensive in-home inhibitor management program, IMPACT helps families affected by hemophilia with inhibitor options, education and personal support.


  • Can I Use Diplomat?

    Can I Use Diplomat?

    We provide benefits investigation and help verify your eligibility for our programs and services. Fill out a simple form and we’ll get in touch with you.
  • Financial Assistance

    Financial Assistance

    We help connect patients with nonprofit, manufacturer-sponsored and third-party funding options to keep therapy affordable.
  • Hemophilia of North Carolina Educational Scholarship Program

    Hemophilia of North Carolina Educational Scholarship Program

    All bleeding disorder patients, siblings, caregivers or parents pursuing higher education or professional training are encouraged to apply.
  • It’s Always About Nate

    It’s Always About Nate

    The fourth in the “Nate” series, this children’s story explores how bleeding disorders affect parents’ and siblings’ lives too—and how a little compassion can go a long way.
  • The Great Inhibinator

    The Great Inhibinator

    By working through his feelings with his family, six-year-old Nate finds a way to feel powerful despite his inhibitor diagnoses.
  • StrapWrap®


    Able to fasten to seatbelts, bag straps and bicycles, the StrapWrapⓇ keeps medical history and information secure and accessible to emergency responders.
  • Hemophilia Newsletter

    Hemophilia Newsletter

    Stay current on news, tips, stories, advancements and more from the hemophilia community. Available via email or print.
  • Kids Hemophilia Calendar Contest

    Kids Hemophilia Calendar Contest

    Children with bleeding disorders and their families are invited to submit artwork for this year’s calendar contest.
  • Be a Hero Mat

    Be a Hero Mat

    This mat provides a clean surface to help children learn to infuse at home, with clear instructions and colorful illustrations.

Featured Technology

A mobile health care application for patients with hemophilia and related bleeding disorders. The app helps patients conveniently track their personal infusion records and bleeding event history, as well as share important injury and treatment information with members of their health care team.

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