Factor I deficiency (or congenital fibrinogen deficiency) is a rare bleeding disorder. People with factor I deficiency have problems with a substance in the blood called factor I protein. As a result, they bleed easily after minor trauma or surgery. They can even bleed with no explanation.
Bleeding from the nose, gums, or tongue is common with all three types. Some patients bleed internally, with blood collecting in joints and around muscles. Rarely, bleeding can occur in the brain or other internal organs. Women with congenital afibrinogenemia can bleed more than usual during menstruation. They might need treatment to carry a pregnancy to term.
Afibrinogenemia affects about 150–300 people in the United States. The other two types are even more rare. Patients are usually diagnosed between birth and early childhood.
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