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Learn More About Factor X Deficiency


Factor X deficiency can be inherited or acquired.

    -The inherited form is caused by mutations in the F10 gene, which provides instructions for making coagulation factor X. These mutations can lead to Type 1 or Type 2 factor X deficiency. In Type 1, the blood doesn’t have enough coagulation factor X. In Type 2, the coagulation factor X doesn’t work.

    -The acquired form can be caused by other disorders, such as severe liver disease or systemic amyloidosis. It can be caused by certain drugs (such as medicines that prevent clotting) or by a deficiency of vitamin K.


Traditionally, factor X deficiency was treated with prothrombin complex concentrates, which carried the risk of blood clots. Today, factor X deficiency can be treated with Coagadex® (coagulation factor X [human]), available through Diplomat Specialty Infusion Group.


Genetics Home Reference, Food and Drug Administration, National Hemophilia Foundation

The information contained herein may not be construed as medical advice. It is for educational purposes only. Diplomat Pharmacy Inc. takes no responsibility for the accuracy or validity of the information contained herein, nor the claims or statements of any manufacturer. Reference to a specific product, process, or service does not constitute an endorsement or recommendation by Diplomat Pharmacy Inc. Any such reference is provided for educational purposes only.